1b. 239. Corresponding author. Direct binding or competition assay...Institute of Structural Biology, University of BonnJoin ResearchGate to find the people and research you need to help your work.Only verified researchers can join ResearchGate and send messages to other members.University students and faculty, institute members, and independent researchersTechnology or product developers, R&D specialists, and government or NGO employees in scientific rolesHealth care professionals, including clinical researchersJournalists, citizen scientists, or anyone interested in reading and discovering researchSorry, you need to be a researcher to join ResearchGate.Due to our privacy policy, only current members can send messages to people on ResearchGate.© 2008-2020 ResearchGate GmbH. Search for articles by this author . In the present work the interaction
Active Cdk12/CycK is arranged in an open conformation similar to that of Cdk9/CycT but different from th...Patients with HIV are at an increased risk of cardiovascular disease. Network. All life on earth probably started with a common ancestral cell approximately 4 billion years ago.
Unexpected findings now suggest that TLR8 recognizes RNA degradation products rather than ssRNA and that synergistic binding of two ur...Most simian immunodeficiency viruses use their Nef protein to antagonize the host restriction factor tetherin. Specific binding of hGBP1 to guanine nucleotides has been established although only two classical GTP-binding motifs were found in its primary sequence. Scale bars: 250 μm. Bisherige Therapieansätze konzentrieren sich auf die Hemmung viraler Enzyme und sind aufgrund der Entwicklung von Resistenzen sowie der großen Nebenwirkungen nicht ausreichend. Phase contrast time-lapse microscopy performed on representative examples of mock RNAi- and FMNL2+3 RNAi-treated B16-F1 cells. The Geyer lab is interested in the regulation of transcription and the molecular mechanisms that govern immune receptor activation.
In contrast, MYC turnover is essential for recruitment of TRR...The potential role of the human immunodeficiency virus-1 (HIV-1) accessory protein Nef in the pathogenesis of neuroAIDS is still poorly understood. Using CRISPR-Cas9 homology-directed repair, we g...Alzheimer’s disease is the world’s most common neurodegenerative disorder. the kinase activity of P-TEFb for phosphorylation of the C-terminal domain (CTD) of RNA polymera...Phosphorylation of the RNA polymerase II C-terminal domain (CTD) by cyclin-dependent kinases is important for productive transcription. Based on previous studies showing apoptosis-associated speck-like protein containing a CARD (ASC) binding and cross-seeding extracellular Aβ, we investigate the propagation...Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR) and mRNA processing. Cdk13 contains a C-terminal extension helix composed of a polybasic cluster and a DCHEL motif that interacts with the bound ATP. Affiliations. Affiliations. 2. In this mechanism an N-terminal domain (inactivation gate), which...Controlling the hydrolysis rate of GTP bound to guanine nucleotide binding proteins is crucial for the right timing of many biological processes. Here, we show that following genotoxic stress, the RNA-binding motif protein 7 (RBM7) stimulates RNA polymerase II (Pol II) transcription and promotes cell viability by activating the positive transcription elongation factor b (P-TEF...Cyclin-dependent kinase 7 (CDK7) regulates both cell cycle and transcription, but its precise role remains elusive. The formins FMNL2 and FMNL3 are Cdc42 effectors targeting to the lamellipodium tip and shown here to nucleate and elongate actin filaments with complementary...Analysis of formin-mediated filament elongation in the presence of profilin.Related to Fig. Here we determine the crystal structure of Cdk12/CycK and analyse its requirements for substrate recognition.
Consistently, FMNL3-EGFP showed prominent accumulation...Visualization of FMNL-mediated actin filament generation by TIRF microscopy.Related to Fig.
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